Moscow Region has been the first region in the Russian Federation that introduced HPV vaccination program for girls 13-15 years of age in 9 districts in 2008. Genital warts (GW) are the first clinical enpoint to study when investigating effectiveness of quadrivalent HPV vaccine. The aim of our study was to evaluate effectiveness of HPV vaccination program after 5 years of introduction in 3 districts of Moscow region with different coverage of vaccine.
Ecological study based on annual reports of gynecologists of adolescents on incidence of GW among 10-17 aged girls in 3 districts of Moscow region: Naro-Fominsk, Kolomna and Egorievsk with 4-valent HPV vaccine coverage in 13-15 aged girls population 80%, 30% and 0% respectively. Trends in incidence of GW were calculated from 2009 to 2014 among 10-17 aged girls.
Significant decline in incidence of GW was observed in Naro-Fominsk district with 4-valent HPV vaccine uptake 80% (from 9,3 per 100 000 to 3,8 per 100 00), followed by Kolomna with 30% vaccination coverage (from 6,2 per 100 000 to 4,8 per 100 000). In contrast with Naro-Fominsk and Kolomna the incidence of GW in Egorievsk district (without introduced HPV vaccination program) had increased (from 8,4 per 100 000 to 10,1 per 100 000)
This data suggests that high-coverage HPV-vaccination programs may result in a rapid reduction of GW ( first marker of effectiveness for 4-valent HPV vaccine). In the longer term, substantial reductions in the rates of cervical, vulvar, vaginal and anal cancers may follow.