As HPV vaccine coverage increases and demonstrated reductions in cervical precancer and cancer are confirmed, countries will need to reconsider current approaches to screening. Modeling can be used, in conjunction with epidemiologic data, to suggest optimal screening strategies in the era of HPV vaccines. This talk will provide an overview of current issues in determining how best to change screening and will highlight some of the areas of uncertainty using recent data from the US in combination with a simulation model. The areas of uncertainty include how best to account for herd immunity, if at all and whether women will adhere to screening recommendations once vaccinated.
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