MSS 05-07ALTERNATIVE VACCINATION STRATEGIES

05. HPV prophylactic vaccines
M. Elfström 1, F. Lazzarato 2, S. Franceschi 3, J. Dillner 4, I. Baussano 3.
1Department of Laboratory Medicine, Karolinska Institutet, Stockholm; Regional Cancer Center of Stockholm-Gotland (Sweden), 2Department of Translational Medicine, University of Piemonte Orientale Avogadro, Novara, Italy; Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Italy; International Agency for Research on Cancer, Lyon (France), 3International Agency for Research on Cancer, Lyon (France), 4Department of Laboratory Medicine, Karolinska Institutet, Stockholm; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Sweden)

Background / Objectives

Discussions on extending catch-up vaccination efforts and including males in vaccination programs have intensified as vaccine programs targeting females have taken hold and evidence has mounted regarding herd protection effects and HPV-associated disease in men. As vaccination strategies further developed, issues related to overall, in-population effectiveness and resilience of the program need to be explored. 


Methods

Comparing alternative vaccination strategies using models based on real-life program data can provide strong predictions for anticipated effectiveness. Two main questions are the impact of extending catch-up vaccination to older females and including males in routine and possibly catch-up vaccination efforts. 


Results

Conclusion

Evidence from a validated model calibrated to Swedish data suggests that with extended catch-up of females, decreases in the burden of vaccination-preventable HPV infections can be accelerated as compared to routine school-based vaccination of young girls. Including males in routine vaccination increases the resilience of vaccination programs, minimizing the potential loss of effectiveness due to unexpected drops in vaccine coverage.

 


References