The purpose of this study was to investigate the association between the treatment for CIN with cervical conization or LLETZ and the obstetric outcome. The main obstetric outcome was gestational age of delivery, neonatal biometry and neonatal condition at birth.
Data was collected from 1382 women who received a conization between 2004 and 2012. In this group 108 patients were identified whom had a subsequent delivery. 22 women had two subsequent deliveries, 2 women had 3 subsequent deliveries. A control group was composed based on a match for every patient by maternal age at delivery, year of delivery and parity.
Only a significant lower birth weight could be found (3118 ± 607 vs. 3299 ± 646 P<0.01) in the study group. Non-significant higher rates of preterm delivery (RR 1.42 CI 0.75 – 2.71) and severe preterm delivery (RR 3 CI 0.83 – 10.84) were found in the treatment group. There was no significant difference in gestational age of delivery (270 ± 19 vs. 272 ± 17 P=0.14), neonatal length (49 ± 3 vs. 50 ± 3 P=0.09) and neonatal head circumference (34 ± 2 vs. 34 ± 2 P=0.48) between the study group and the control group.
Treatment of CIN by performing conization of LLETZ did not significantly affect the gestational age of delivery in the University Hospital of Leuven. However a significant lower birth weight could be found in the study group. Although matching, residual confounding cannot be excluded.