To evaluate the histologic outcomes and clinical significance of patients with atypical glandular cells detected either on conventional smears and liquid based cytology.
A retrospective analysis of the pathology database of AGC diagnosed on cytology between 2000 and 2016 in seven tertiary medical centers in korea. Cytohistological correlation of 131 patients was performed. Significant lesions included high-grade squamous intraepithelial lesion, adenocarcinoma in situ (AIS), cervical cancer, endometrial hyperplasia (EH), endometrial cancer and other malignancies.
Mean age was 46.4 years. 60 (45.8%) of 131 patients were confirmed as having clinically significant lesions comprising cervical intraepithelial neoplasia (CIN) II-III (9.2%), squamous cell carcinoma in situ (CIS) (4.6%), adenocarcinoma in situ (AIS) (8.4%), cervical cancer (15.3%), endometrial hyperplasia (0.8%), endometrial cancer (6.1%) or other malignancies (1.5%). The prevalence of significant pathologies in women with AGC was significantly higher compared with normal cytologic diagnosis.
This study highlights the clinical importance of the AGC on cytology associated with underlying significant pre-invasive and invasive lesions. So more aggressive assessment strategy for AGC is warranted.