As part of the Framework for Modeling HPV Prevention (HPV-FRAME) consortium, general principles for models of HPV vaccination and for models of cervical screening will be presented. This talk will present the additional draft HPV-FRAME reporting requirements for parameters for evaluations of HPV prevention in low- and middle-income countries (LMIC).
We identified distinct parameters and assumptions that are critical to specify in model-based analyses of vaccination and/or screening in LMIC. In addition to the general requirements for reporting on country- or setting-specific information on burden of infection and disease, analyses in LMIC should report assumptions of the feasibility of implementation and sustainability of screening or vaccination programs, as well as the data that inform these assumptions. This includes scenarios of current "status quo" practice (e.g., existing immunization programs and existing screening programs), as well as specification of additional constraints that may inhibit implementation and scale-up of intervention(s). Analyses of vaccination should report on the assumed vaccine target population(s) and corresponding delivery mechanism. Budget or cost effectiveness evaluations should specify currency (and year) for costs, as well as the method of cost inflation and/or conversion, for example, using purchasing power parity index for comparisons across settings and assumptions of tradeable versus non-tradeable goods. The willingness to pay threshold for a particular country should be clearly specified and justified.
Analyses in the context of LMIC should be held to the same reporting standard as those for high income countries (specified in the general principles for models of HPV vaccination and cervical screening). In addition, there are inputs that are unique to analyses in LMIC that are also important to disclose to ensure proper interpretation of results, to enable assessment of quality of the analysis, and to facilitate comparison across other studies.