STC 01 A-01The new ISSVD and consensus terminologies of Vulvar Squamous Intraepithelial Lesion (VSIL) and Vulvodynia

19. Vulvar diseases and neoplasia
J. Bornstein 1.
1Galilee Medical Center and Bar-Ilan University. Chairman ISSVD terminology Committee (Israel)

Background / Objectives

VSIL terminology: The introduction of the LAST raised two concerns in relation to vulvar lesions: the absence of reference to "differentiated VIN". Secondly, including the term: 'low grade squamous intraepithelial lesion' (LSIL) in LAST recreated the potential for over-diagnosis.
Vulvar pain and Vulvodynia: New research led to better understanding of the physiology and pathogenesis.


Methods

VSIL terrminology: The terminology committee of the ISSVD discussed several new terminology options.

Vulvar pain and Vulvodynia: The ISSVD, together with ISSWSH and IPPS held a consensus conference. 


Results

VSIL terminology: 
•    Vulvar LSIL, encompassing flat condyloma or HPV effect
•    Vulvar HSIL (VIN usual type) 
•    VIN, differentiated-type (DVIN)


2015 Consensus terminology and classification of persistent vulvar pain and vulvodynia
 A. Vulvar pain caused by a specific disorder*
•    Infectious
•    Inflammatory
•    Neoplastic
•    Neurologic
•    Trauma  
•    Iatrogenic
•    Hormonal deficiencies

B. Vulvodynia – Vulvar pain of at least 3 months' duration, without clear identifiable cause, which may have potential associated factors 
    Descriptors: 
•    Localized or Generalized or Mixed (localized and generalized)
•    Provoked or Spontaneous or Mixed (provoked and spontaneous) 
•    Onset (primary or secondary)  
•    Temporal pattern (intermittent, persistent, constant, immediate, delayed)
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*Women may have both a specific disorder (e.g. lichen sclerosus) and vulvodynia

2015 Consensus terminology and classification of persistent vulvar pain and vulvodynia 
Appendix: Potential factors associated with Vulvodynia*
•    Co-morbidities and other pain syndromes [Level of evidence 2]
•    Genetics [Level of evidence 2]
•    Hormonal factors (e.g. pharmacologically induced) [Level of evidence 2]
•    Inflammation [Level of evidence 2]
•    Musculoskeletal [Level of evidence 2]
•    Neurologic mechanisms: 
   -   Central (spine, brain) [Level of evidence 2]
   -   Peripheral – Neuroproliferation [Level of evidence 2]
•    Psychosocial factors [Level of evidence 2]
•    Structural defects [Level of evidence 3]


Conclusion

VSIL terrminology: The new terminology includes all types of vulvar squamous intraepithelial lesionsand create unity among clinicians and pathologists.

Vulvar pain and Vulvodynia: The new terminology incorporates new information derived from evidence-based studies conducted since the last terminology introduced in 2003.

 


References