It seems to be difficult for young Japanese girls to seek gynecological clinic and mount on the examining table because of embarrassment. In order to increase rate of cervical cancer examining test in young girls, it may reasonable to adopt HPV self-harvesting test(S sample). However, before adopting self-harvesting test, it is necessary to verify the superiority or non-inferiority of that compared to harvesting by a gynecologist (G sample). In this report, the superiority of self-harvesting test was examined.
Seventy four patients having more than slight dysplasia of the cervical region were examined in this study by using paired samples taken by a gynecologist and a patient herself in the same visiting date. Samples were examined by using a kit of GENOSEARCH HPV 31 which can identify 31 HPV genotypes including 13 high risk and 18 low risk HPV types.
In a result, HPV positive rate was higher but not significant in S samples of 78.4% (58/74 cases) compared to that in G samples of 70.3% (52/74 cases). Superinfection of HPV was likely to be detected more often in S samples than G samples . In each type of high risk HPV, positive case number of S samples was superior to that of G samples in most HPV types (7 vs 1).Quite same was observed in the case of low risk HPV (7 vs 1).
In summary, the HPV positivity of S samples was superior to that of G samples. It is considered that HPV sample-harvesting by patient herself is very useful not only for early diagnosis but also for early treatment of cervical cancer.
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