Given the high incidence of cervical cancer in developing countries and the importance of prompt diagnosis and treatment regarding mortality reduction, developing accurate and cost-effective method for screening and diagnosis of this cancer has occupied the minds of physicians for years. Previous studies reported high diagnostic accuracy for Pap smear, VIA, and VILI with respect to cervical cancer. Moreover, not all developing countries have access to colposcopy. Therefore, this study was attempted to compare these three tests with colposcopy in terms of diagnostic value.
. This diagnostic study was conducted on 328 women referred to Shahid Sadoughi Clinic for colposcopy. At the first step, Pap smear was performed for those who did not undergo this test previously. Then, all the participants underwent VIA and VILI tests according to the known protocol. Next, colposcopy was conducted for all the participants, biopsy sample was obtained, and histological features were studied. Finally, the results were compared based on statistical indicators.
Sensitivity of 91.9% and specificity of 53.6% were obtained when Pap + VILI + VIL test results were compared with biopsy.
Positive predictive value of 20% and negative predictive value of 98% achieved.
A diagnostic accuracy of 58% was gainedIn case of positive CIN II results and higher degrees of CIN, the findings were as follows when colposcopy results were compared with biopsy ones:
Sensitivity of 86.5% and specificity of 95.5% were obtained.
Positive predictive value of 71.1% and negative predictive value of 98.2% were acquired.
A diagnostic accuracy of 94% was attained .
According to our findings, Pap+ VIA+ VILI test results are comparable with colposcopy ones in terms of diagnostic accuracy (73% and 75%, respectively). Therefore, Pap+ VIA+ VILI test is recommended as a competent alternative to colposcopy in developing countries.
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