FC 10-09THE 5-YEAR INCIDENCE AND CLEARANCE OF TYPE-SPECIFIC HPV IN A SCREENING COHORT IN CHINA

11. Genotyping
R. Rezhake 1, Q. Zhang 1, L. Dong 1, S.Y. Hu 1, R.M. Feng 1, X. Zhang 1, Q.J. Pan 1, J.F. Ma 2, Y.L. Qiao 1, F.H. Zhao 1.
1National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China (China), 2Xiangyuan Women and children’s Hospital, Changzhi, Shanxi Province, 046200, China. (China)

Background / Objectives

We aimed to evaluate the 5-year incidence and clearance of type-specific high-risk HPV (hr-HPV) among a Chinese rural women cohort.


Methods

A screening cohort with 1,997 women aged 35-45 years was followed up with an interval of approximate 5 years. HPV genotyping (INNO-LiPA Extra, Innogenetics, Belgium ) was performed on cervical samples collected from HPV positive women (Hybrid Capture II) in this cohort since 2005. The 5-year incidence and clearance of type-specific HPV and the relevant demographic factors were calculated.


Results

The 5-year overall incidence of hr-HPV was 15.6% and the clearance was 69.0%. HPV 16 related types had two times probability of HPV incidence (10.6%) after 5 years than HPV 18 related types (4.4%) (P<0.001), while the clearance of HPV 16 related types (74.1%) was lower than that of HPV 18 related (85.9%) (P=0.048). The incidence and clearance of HPV 16 was 2.7% and 70.9%. HPV 52 and 16 ranked the top of hr-HPV incidence and HPV 52 and 18 ranked the top of hr-HPV clearance. Sexual debut age was the main factors correlated with HPV incidence, with the adjusted RR of 1.478 (95%CI: 1.110-1.967).


Conclusion

The high incidence, persistence and low clearance prompted the importance of screening in HPV 16 related positive mid-adult Chinese women. Women with HPV 16 related repeated positive within 5 years should be considered as a high risk population for cervical cancer.


References