P20-03Evaluation and correlation of primary histopathological diagnosis of targeted biopsy till the final histopathological diagnosis following diagnostic and therapeutic process of leep conization

20. Diagnostic procedures / management
D. Pruski 1, A. Lewek 2, S. Millert 3, W. Kedzia 1.
1Division of Gynecology, Department of Perinatology and Gynecology, Gynecology and Obstetrics Clinical Hospital, Karol Marcinkowski University of Medical Sciences Poznan Poland. Laboratory of Cervical Pathophysiology, Gynecology and Obstetrics Clinical Hospital, Karol Marcinkowski University of Medic (Poland), 2Division of Gynecology, Department of Perinatology and Gynecology, Gynecology and Obstetrics Clinical Hospital, Karol Marcinkowski University of Medical Sciences Poznan Poland. (Poland), 3Laboratory of Cervical Pathophysiology, Gynecology and Obstetrics Clinical Hospital, Karol Marcinkowski University of Medical Sciences Poznan Poland. (Poland)

Background / Objectives

Evaluation of consistency of the final histopathological diagnosis following diagnostic and therapeutic process of leep conization till the primary histopathological diagnosis following targeted cervical biopsy.


Methods

The analysis included 540 patients, in whom leep conization was performed due to incorrect result following targeted biopsy – SIL or discrepancy of cytological – histopathological results.Targeted biopsy and leep conization were performed by doctors with years of experience. Colposcopy was performed using  stereoscopic colposcope (Olympus OCS-500). Colposcopic pictures were evaluated according to Reid’s index, regarding the margin and acetowhitening, iodine negative test and vascularization.


Results

The most frequent histopathological diagnosis following targeted biopsy and  leep conization were HGSIL-CIN 2 type changes, which   comprised 36% and 34% respectively and HGSIL-CIN 3 type changes which comprised 21% and 27% respectively. Conistency of histopathological results of targeted biopsy compared to the final result following leep conization comprised  94% for HGSIL type changes.


Conclusion

Targeted cervical biopsy and leep conization show very high consistency in terms of histopathological results.


References