FC 06-09Type-specific human papillomavirus profile, absolute risk and attributable fraction to cervical cancer and precancerous lesions –a population-based study of 3,083 women in Inner Mongolia, China.

11. Genotyping
L. Li 1, W. Chen 2, Y. Qiao 2, L. Wang 3, M. Jiang 2, R. Feng 2, T. Li 2.
11.School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region, China (China), 23.Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; 17 South Panjiayuan Lane, P.O. Box 2258, Beijing 100021, China (China), 33.Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; 17 South Panjiayuan Lane, P.O. Box 2258, Beijing 100021, China/ Department of Basic Medical Sciences, Cancer Research Center, Medical College, Xiamen Uni (China)

Background / Objectives

Given the variation of region-specific HPV genotypes prevalence, knowledge about the distribution of human papillomavirus (HPV) genotypes in general population and their attribution to high-grade cervical lesions is crucial to guide the introduction of prophylactic vaccines and the implementation of cervical cancer screening. Few studies, however, comprehensively focused on the HPV genotypes profiles in such high-risk regions with ethnic minority as Inner Mongolia, in China.To analyze the HPV genotypes characteristics and the presence of multiple HPV infections among general population and estimate type-specific absolute risk and relative contributions to cervical intraeptithelial neoplasia grade 2 or worse (CIN2+) .


Methods

Between Jun and Aug 2016, 3,083 women aged 21–64 years were enrolled in a cervical cancer screening study in Inner Mongolia Province, China. Each participant was examined by Hybrid Capture 2 testing and liquid-based cytology. Women positive with any screening results were referred to colposcopy and biopsy was taken if necessary. All cervical cytological cells were tested using SPF10-LIPA system to discriminate 28 HPV genotypes. Absolute risk of cervical (CIN2+) for type-specific HPV was calculated and the corresponding attribution to cervical lesions was estimated using a fractional contribution approach.


Results

High-risk HPV (HR-HPV) prevalence was 17.5% and abnormal cytology rate was 14.2% in the general population. Most five common genotypes were HPV 52, 39, 16, 51, 58. Multiple-type infection rate varied by age and peaked at women with 50 years old and more (12.0%). Women infected with HPV16 were at highest absolute risk of CIN2+ at 28.7%, followed by HPVs 58, 33, 35, 18 and 52 at 12.0%, 11.8%, 9.5% and 9.3%, 8.8% respectively. Attributable fraction (AF) to CIN2+ differed by type-specific HPV and was predominated by HPV 16 with the AF of 54.9%, followed by HPV 52 (52.4%), HPV 39 (4.6%), HPV 58 (2.7%), HPV18 (1.9%).


Conclusion

Type-specific high-risk HPV-DNA-based screening tests and protocols and introduction of polyvalent HPV vaccines might give the priority to HPV types 16, 18, 52 and 58 in the high-risk region in China, as their high prevalence, high absolute risk and notable attributable fraction to high-grade cervical lesions.


References