“Composite Intrinsic Capacity” 

Philipe de Souto Barreto, PhD, IHU HealthAge, Toulouse (France) 

 

Philipe de Souto Barreto is Professor at Université Paul Sabatier Toulouse 3, Director of the Institute on Aging at the Gerontopole of the Toulouse University Hospital (WHO Collaborating Center on Frailty, Clinical & Geroscience Research & Geriatric Training), and member of the Management Board of the IHU HealthAge (an Institute dedicated to Geroscience and Healthy Longevity). PhD in Bio-cultural Anthropology, Professor Barreto’s main field of expertise is on physical activity and exercise during aging, having participated in the elaboration of international guidelines, task forces and consensus papers on this topic. He has leaded and participated in international taskforces on topics related to frailty, intrinsic capacity and Geroscience. Philipe contributed to several national and international research projects as PI, local PI, and co-investigator (including the INSPIRE platform on Geroscience and the Institute IHU HealthAge). Dr Barreto has been invited speaker at national and international congresses and has published more than 250 peer-reviewed papers in prestigious Journals, including JAMA Int Med, BMJ, Nat Aging, Lancet Healthy Longev. He currently serves as co-Editor-in-Chief of the Journal of Nutrition, Health & Aging (Q1 in both Geriatrics & Nutrition). 

 

 

 

 

 

“Senescent Cells from Translational Research to Clinical Studies”  

Nathan LeBrasseur, PhD, Mayo Clinic, Rochester, MN (USA) 

 

 

Nathan LeBrasseur, PT, PhD, is a Professor in the Department of Physical Medicine and Rehabilitation and has a joint appointment in the Department of Physiology and Biomedical Engineering at Mayo Clinic. Dr. LeBrasseur is the Director of the Robert and Arlene Kogod Center on Aging, the Co-Director of the Paul F. Glenn Center for Biology of Aging Research, and Scientific Director of the Office of Translation to Practice at Mayo Clinic. He is the recent chair of the NIH Cellular Mechanisms in Aging and Development Study Section. Dr. LeBrasseur’s research team conducts translational “bench-to-bedside” research on strategies to improve physical function, metabolism, and resilience in the face of aging and disease. His latest work has centered on cellular senescence, a fundamental mechanism of aging, and interventions to counter this process to extend healthspan. Dr. LeBrasseur has received the Glenn Award for Research in Biological Mechanisms of Aging, the Nathan W. Shock Award Lecture from the National Institute on Aging, and the Vincent Cristofalo Rising Star Award in Aging Research from the American Federation for Aging Research. He is a Fellow of the Gerontological Society of America. 

 

 

 

 

 

“Translational geroscience interventions for frailty”  

John Newman, MD, PhD, Buck Institute for Research on Aging, Novato, CA (USA) 

 

John Newman, MD, PhD, is a physician-scientist who is Assistant Professor at the Buck Institute for Research on Aging and Associate Professor of Medicine in the Division of Geriatrics at University of California San Francisco (UCSF). His career goal is to apply our expanding understanding of aging biology to geriatric syndromes such as frailty and delirium in order to improve the care and help maintain the independence of older adults. A key theme of his research program is how fasting-related metabolic pathways, especially ketone bodies, interact with mechanisms of aging. His translational bench-to-bedside laboratory spans biochemistry to mouse models to clinical trials. Dr. Newman is also a geriatrician who cares for hospitalized older adults at UCSF and the San Francisco VA Medical Center, focusing on preserving mobility and preventing delirium. His undergraduate education was at Yale University, with a BS/MS in molecular biophysics and biochemistry, and he completed an MD/PhD at the University of Washington with a PhD in Biochemistry. He then completed residency in internal medicine and fellowship training in geriatric medicine at UCSF, and a postdoctoral fellowship at the Gladstone Institutes, before starting his independent laboratory at Buck in 2018. He is an National Institute on Aging Beeson Scholar. 

 

 

 

 

 

“How Frailty Concepts Have Changed Clinical Practice” 

Cornel C. Sieber, MD, PhD Friedrich-Alexander-Universität Erlangen-Nürnberg, Nuremberg (Germany) 

 

 

Cornel C. Sieber is Director of the Institute for Biomedicine of Aging (IBA) at the Friedrich-Alexander-Universität Erlangen-Nürnberg. He is also CMO at Kantonsspital Winterthur (Switzerland) and since 2024 the Immediate Past President of the European Geriatric Medicine Society (EuGMS). He serves on the editorial boards of different local and international journals. His main research interest encompasses the field of malnutrition/sarcopenia and its relation to the frailty syndrome. 

 

 

 

 

 

“Biological Characteristics promoting resiliency and healthy aging”  

Jeremy Walston, MD, Johns Hopkins University, Baltimore, MD (USA) 

 

 

Dr. Walston is the director of the Johns Hopkins Human Aging Project (HAP), is the Raymond and Anna Lublin Professor of Geriatric Medicine and Gerontology, deputy director of the Division of Geriatric Medicine and Gerontology, principal investigator of the Johns Hopkins Older Americans Independence Center, and the co-director of the Biology of Healthy Aging program. His research focus is on determining the biological characteristics that promote resiliency and healthy aging, and on the translation of that knowledge into diagnostic, preventive and treatment strategies that promote a long and healthy life.