Head and Neck Forum - Epidemiology of oral HPV infection
Sunday, December 2, 2018
Workshop
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HN 01
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10:30 AM
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12:00 PM
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Head and Neck Forum - Epidemiology of oral HPV infection
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5B
In the U.S., approximately 70% of oropharyngeal cancers (OPCs) are attributable to human papillomavirus (HPV) infection,
predominantly HPV 16. HPV-related OPC incidence is 4-5 fold higher in men compared to women and is increasing rapidly
among males worldwide. OPC incidence among US men is now higher than cervical cancer incidence in women, with a
significant increase in the proportion of cases attributable to HPV in recent decades. This changing epidemiology of increasing
OPC incidence that is higher than cervical cancer incidence is now observed in several high resource countries, especially
those with robust cervical cancer screening programs. Unfortunately there are no screening tests available for OPC, nor
have current HPV vaccines been proven to protect against these cancers. As a result, most OPC tumors are diagnosed with
advanced disease, with multiple bilateral positive neck nodes. Although treatment outcomes of HPV-related OPC are superior
to those of HPV negative cases, treatment may cause significant morbidity, and rates of recurrence are still 10-30%. Detection
of cancers earlier when tumors can be effectively and safely treated with a single modality provides an opportunity to achieve
cure with limiting adverse consequences. To improve our ability to reduce OPC burden and patient survival and quality of
life, more research is needed. This session will address the first area of research that is essential to the development of
efficacious prevention programs, understanding the epidemiology of oral HPV infections and the factors associated with oral
HPV infections.
10:30 AM
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HN 01-01
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Natural history
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K.
Kristina R
Dahlstrom
10:48 AM
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HN 01-02
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Sex differences
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J-D.
Jean-Damien
COMBES
11:06 AM
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HN 01-03
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Tobacco and other risk factors
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N.
Nosayaba
OSAZUWA-PETERS
11:24 AM
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HN 01-04
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Sampling of oral vs. tonsil
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H.
Haitham
MIRGHANI
11:42 AM
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HN 01-05
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Discussion
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