Myologie Translationnelle
mardi 26 mars 2019
Plenary
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26-AM-Plenary
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09h00
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10h30
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Myologie Translationnelle
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Amphi A
09h00
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S02-01
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Molecular mechanisms regulating muscle satellite cell function
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F.
Frédéric
RELAIX
Objectifs : My lab has a long-standing interest in understanding the regulatory networks of developmental and adult myogenesis, with a specific focus on muscle stem cells (termed satellite cells). Through large-scale screens we have identified the transcriptional and epigenetic shift that is manifested at the quiescence-to-activation switch. We are following up on several factors and pathways that regulate quiescence, activation, differentiation, self-renewal, and the epigenetic landscape of satellite cells. Furthermore, we are investigating the adaptive response of satellite cells to environmental stress. Finally, we have developed a novel protocol that permits the isolation of truly quiescent satellite cells, avoiding the artefacts introduced by current isolation protocols. Using this protocol we are launching a series of high throughput and single cells experiments to uncover the major players of the quiescence and activation networks. Elucidating the networks that command satellite cell quiescence and activation is a major challenge and a requirement to comprehend the remarkable regenerative capacity that muscle displays.
09h30
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S02-02
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Approaches to delay the progression of Muscular Dystrophy
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G.
Graziella
MESSINA
10h00
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S02-03
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Expression and functional analyses of Dlk1 in muscle stem cells and mesenchymal progenitors during regeneration
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S-I.
So-Ichiro
FUKADA
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