The unifying theme of my research concerns the skeletal muscle plasticity associated with physiological stimuli (i.e., Neuromuscular Electrical Stimulation – NMES) or pathophysiological conditions (e.g., myopathies, cachexia associated with cancer or sepsis). I received my PhD degree in Sports Sciences from the University of Burgundy in 2005. My thesis focused on neuromuscular adaptations induced by NMES training. In 2006, I got a postdoctoral position at the Department of Physiology, University of Pavia, Italy where I combined in vivo (force measurements) and in vitro (proteomics, electrophoresis) analyses to define the chronic effects of NMES on human skeletal muscle. Over the last 15 years, my research interests include the investigation of both acute and chronic effects of NMES on skeletal muscle function in both animals and healthy humans. Thanks to a variety of non- invasive methodological tools including electromyography, neurostimulation, functional magnetic resonance imaging and 31P resonance spectroscopy, my works provided key information on the optimal application of NMES thereby opening perspectives to improve (neuro)functional capacities in severely deconditioned patients or suffering neurological damage. Since 2016, I manage the research group “electrostimulation and cachexia” (INMG, Chazaud Team, Lyon; www.musclestem.com) focusing on the effectiveness of carefully-controlled NMES training protocols for minimizing muscle dysfunctions in two pathologies (i.e., cancer and critical illness myopathy).



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